The Ellison Medical Foundation Colloquium on the Biology of Aging will be held Wednesday, August 11 through Friday, August 13, 2010 at the Marine Biological Laboratory, Woods Hole, MA. The Ellison Medical Foundation Senior Scholars and New Scholars from 2006, now in the final year of their awards, will be presenting their research at the colloquium. These Colloquium presentations are open to the public. Directions to the MBL and travel information are available at http://www.mbl.edu/about/visit/directions/index.html.

The Ellison Medical Foundation
COLLOQUIUM ON THE BIOLOGY OF AGING
Wednesday, August 11 –- Friday, August 13, 2010
Marine Biological Laboratory
Lillie Auditorium

AGENDA

Wednesday, August 11, 2010

8:00 – 8:15 Introductions

8:15 – 8:40
Jan Vijg, Ph.D.
Albert Einstein College of Medicine
“Genome instability, aging and disease.”

8:40 – 9:05
Ravi Ranjan, Ph.D.
The University of Texas Health Science Center at San Antonio
“Secret of long-lived Methuselah revealed.”

9:05 – 9:30
Roger McCarter, Ph.D./Gerald McClearn, Ph.D.
Pennsylvania State University
Mechanisms of Longevity-Influencing Quantitative Trait Loci

9:30 – 9:55
Hong Zhang, Ph.D.
University of Massachusetts
Genetic Analysis of Senescence in Mammalian Aging

9:55 – 10:20 Break

10:20 – 10:45
Hui Sun, Ph.D.
University of California, Los Angeles
The Double-edged Sword of a Human Polymorphism Associated with a Major Aging Disease

10:45 – 11:10
Kenneth Paigen, Ph.D.
The Jackson Laboratory
“A. SA b-gal is not a marker of aging in mice. B. The control of genetic recombination in mice and humans

11:10 – 11:35
Andrei Seluanov, Ph.D.
University of Rochester
"Anticancer mechanisms in long lived rodents"

11:35 – 12:00
Tong Li, Ph.D.
The Johns Hopkins University
The Role of gamma-secretase as a Tumor Suppressor

12:00 – 1:00 Lunch

1:00 – 1:25
Gerard Evan, Ph.D.
University of California at San Francisco
"Balancing aging and tumor suppression"

1:25 – 1:50
Frank Slack, Ph.D.
Yale University
Control of life span by developmental timing microRNAs

1:50 – 2:15
David Chan, M.D., Ph.D.
California Institute of Technology
"Mitochondrial dynamics and mtDNA stability."

2:15 – 2:40
Tina Iverson, Ph.D.
Vanderbilt University Medical Center
The molecular contribution of mitochondrial complex II to the ageing process

2:40 – 3:05
Bruno Conti, Ph.D.
The Scripps Research Institute
Reduction of core body temperature prolongs life span of mice fed ad libitum - A transgenic model of calorie restriction?

3:05 – 3:30
Anne Hart, Ph.D.
Brown University
"Stress and longevity in C. elegans".

Thursday, August 12, 2010

8:00 – 8:25
Mitch McVey, Ph.D.
Tufts University
"Error-prone repair of DNA double-strand breaks and aging in Drosophila."

8:25 – 8:50
Kevin Mills, Ph.D.
The Jackson Laboratory
DNA Damage and Aging: Dissecting the Genetic Basis of Aging as a Complex Trait

8:50– 9:15
Sandra Wolin, M.D., Ph.D.
Yale University
"RNA Surveillance Pathways and Potential Links to Aging"

9:15 – 9:40
Malcolm Leissring, Ph.D.
Mayo Clinic Jacksonville
Insulin-degrading enzyme: an old enzyme with new links to Alzheimer’s, diabetes, and regulation of life span

9:40– 10:05
Adam Gazzaley, Ph.D.
University of California at San Francisco
Alterations in Neural Networks Underlying Cognitive Aging

10:05 – 10:35 Break

10:35 – 11:00
Michael Riehle, Ph.D.
The University of Arizona
“The elderly mosquito: Insulin’s role in aging, reproduction, and disease transmission”

11:00 – 11:25
Cheryl Conover, Ph.D.
Mayo Clinic and Foundation
A novel mouse model of diminished IGF signaling and extended lifespan

11:25 – 11:50
Bruce Spiegelman, Ph.D.
Dana-Farber Cancer Institute
Regulation of ROS Metabolism via the PGC-1 Coactivators

11:50 – 12:15
Marni Falk, Ph.D.
The Children’s Hospital of Philadelphia
Impact of free radical production on aging in C. elegans mitochondrial complex I subunit mutants

12:15 – 1:15 Lunch

1:15 – 1:40
David Marcinek, Ph.D.
University of Washington
"Mitochondrial adaptation to oxidative stress in aging and disease"

1:40 – 2:05
Richard Freiman, Ph.D.
Brown University
“A mouse model of premature reproductive aging”

2:05 – 2:30
Benoit Giasson, Ph.D.
University of Pennsylvania
The role of Lrrk2 mutations and aging in causing Parkinson's disease and related disorders

2:30 – 2:55
Toren Finkel, M.D., Ph.D.
NIH, National Heart, Lung and Blood Institute
The mammalian aging regulator klotho is an endogenous circulating Wnt antagonist

2:55 – 3:20
William Ogle, Ph.D.
University of Florida
Hormonal Control of Plasticity and Neurogenesis: Understanding the Molecular Pathways and Gene Dynamics Involved in Age related Memory Decline

Friday, August 13, 2010

8:00 – 8:25
Dylan Taatjes, Ph.D.
University of Colorado
"Molecular mechanisms that control p53 transcriptional activity and premature aging"

8:25– 8:50
Patricia Opresko, Ph.D.
University of Pittsburgh
Molecular Mechanisms of Telomeric DNA Instability Associated with the Human Progeroid Werner Syndrome

8:50 – 9:15
Mel Feany, M.D., Ph.D.
Brigham and Women’s Hospital
Genetic Basis of Age-Dependence in Neurodegenerative Diseases

9:15 – 9:40
Inder Verma, Ph.D.
The Salk Institute for Biological Studies
Novel Gene Delivery Methods in the Brain

9:40 – 10:05
Anshu Agrawal, Ph.D.
University of California at Irvine
'Impact of aging on human dendritic cell function'.

10:05 – 10:35 Break

10:35 – 11:00
Chris Schaffer, Ph.D.
Cornell University
Blood, Brains, and Lasers: Imaging microvascular disease in the brain of rodent models

11:00 – 11:25
Joseph McCarty, Ph.D.
U.T. M.D. Anderson Cancer Center
The Neurovascular Unit and Age-Related Neurodegeneration

11:25 – 11:50
Alexander Hoffmann, Ph.D.
University of California, San Diego
"NFkB in aging and senescence"

11:50 – 12:15
Jenny Hsieh, Ph.D.
University of Texas Southwestern Medical Center at Dallas
"Epigenetic control of adult hippocampal neurogenesis and age- related cognitive decline"

12:15 – 1:15 Lunch

1:15 – 1:40
Margaret Goodell, Ph.D.
Baylor College of Medicine
Mechanisms of Aging in Hematopoietic Stem Cells

1:40 – 2:05
Mark Davis, Ph.D.
Stanford University
"Analyzing influenza vaccine responses in older versus younger individuals."

2:05 – 2:30
Hidde Ploegh, Ph.D.
Whitehead Institute for Biomedical Research
Glycoprotein quality control in the immune system and agein

2:30 – 2:55
E. John Wherry, Ph.D.
The Wistar Institute
Cell-Extrinsic Regulation of Age-Related Deficits in Immune Responses to Infections

 

3rd Annual Joshua Lederberg Lecture 8:00 pm Lillie Auditorium Introduction by Gerald Weissmann, M.D. Speaker Woodring E. Wright, M.D., Ph.D. University of Texas Southwestern Medical Center at Dallas "“Telomere Biology in Aging and Cancer”"