Genomic instability has been implicated as a major cause of aging. Two of the most dynamic components of the genome are transposon--jumping genes, and telomeres--chromosome ends. Transposon silencing and telomere maintenance therefore represent two fundamental activities that ensure genomic stability. Recently, we and others discovered that...
Senior and New Scholars Awards for Yale University
Dr. Haifan Lin
Yale University
2010 senior Scholar Award in aging
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Dr. Marc Hammarlund
Yale University
2010 new Scholar Award in aging
A striking feature of early, normal aging in neurons is loss of plasticity and regenerative growth in response to injury. The mechanisms that link aging to intrinsic loss of regeneration are unclear. A better understanding of the aging mechanisms that govern loss of regeneration is critical for improving regeneration itself, to aid in recovery...
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Dr. Christian Schlieker
Yale University
2010 new Scholar Award in aging
The recent realization that genes involved in protein quality control exert a major impact over life span has spurred efforts to investigate the relationship between protein homeostasis and aging.
Much remains to be learned about the involvement of protein turnover in nuclear envelopathies. Premature aging syndromes are examples of this type... |
Dr. Frank J. Slack
Yale University
2006 senior Scholar Award in aging
Changes in gene expression in aged adults across species do not solely seem to be implemented in response to mounting cellular damage; rather, conserved, developmentally-timed transcriptional regulation during young adulthood seems to control features of aging. For example, early adult C. elegans and Drosophila animals turn off a...
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Dr. Josephine Hoh
Yale University
2005 new Scholar Award in aging
We have uncovered the complement factor H (CFH) being a major gene for Caucasian patients with age-related macular degeneration (AMD). At present, little is known about differences in genetic risk factors contributing to AMD among various ethnic backgrounds. Are the specific clinical feature caused by the same gene in Asians, Caucasians as well...
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Dr. Sandra L. Wolin
Yale University
2006 senior Scholar Award in aging
A consequence of normal cellular respiration is the formation of reactive oxygen species, small molecules that can react with a variety of cellular components. Many studies have suggested that the interaction of reactive oxygen species with cellular structures contributes to aging and neurodegenerative disease. However, while much effort has...
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Dr. David A. Spiegel
Yale University
2008 new Scholar Award in aging
Aging is characterized by the declining ability to respond to stress, increasing homeostatic imbalance, and increased risk of disease. Advanced glycation end-products (AGEs) may provide the scientific explanation for how and why many of the medical complications of the aging process occur. AGEs form spontaneously in the body as people age via the...
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Dr. Anna Elizabeth Rhoades
Yale University
Role of Aging-Related Protein and Lipid Modifications on alpha-Synuclein/Model Membrane Interactions
2007 new Scholar Award in aging
In Parkinson's disease the death of dopaminergic neurons in the brain results in the progressive loss of control of body movement. An estimated 1% of the population aged 65 and older suffers from Parkinson's disease, making it the most common neurodegenerative movement disorder. With this fraction of the population growing more rapidly than... |
Dr. John Carlson
Yale University
2004 senior Scholar Award in gid
One of the most effective means of controlling insect-borne diseases has been to control the insects that carry them. One simple, inexpensive, and environmentally benign means of insect control is the use of repellents and traps. Repellents are used in many countries against mosquitoes, and traps are used in Africa to reduce populations of...
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Funded Institutions
The Ellison Medical Foundation fosters research by means of grants-in-aid on behalf of investigators to universities and laboratories within the United States. Institutions receiving awards must be tax-exempt 501(c)(3) organizations or U.S. colleges or universities.
The Ellison Medical Foundation