Only a handful of interventions are known to extend lifespan in mammals. Among these, dietary restriction is the best established. In a recent study by Harrison and others, rapamycin was the first drug demonstrated to increase mammalian lifespan. However, all known interventions that affect aging are accompanied by detrimental side effects....
Senior and New Scholars Awards for Jackson Laboratory
Dr. Gary Churchill
Jackson Laboratory
2010 senior Scholar Award in aging
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Dr. Beverly Paigen
Jackson Laboratory
2009 senior Scholar Award in aging
The major goal of our program is to identify aging genes in the mouse and then to test those genes in humans. The testing in humans will be carried out in collaboration with Dr. Joanne Murabito of Boston University, who will test these genes in individuals who have lived to at least 90 years of age compared with a control group. For those genes...
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Dr. Kenneth Paigen
Jackson Laboratory
2006 senior Scholar Award in aging
We sense aging as something that happens to our bodies, but as scientists we know that the underlying causes lie in the subtle, and sometimes not so subtle, changes that go on in our cells. We also know that these changes are complex and that they progress in many tissues. As yet, no one has found one simple, unitary explanation, although the...
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Dr. Shirng-Wern (Sharon) Tsaih
Jackson Laboratory
2007 new Scholar Award in aging
This project will develop novel methods for causal inference utilizing multiple age-related phenotypes collected on a panel of mouse inbred stains across a range of ages at the Jackson Laboratory Integrative Center for Genetic Regulation of Aging. This unique study of mammalian aging will accelerate the pace of aging research. Graphical models...
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Dr. David E. Harrison
Jackson Laboratory
2007 senior Scholar Award in aging
Precursor cells that continuously regenerate are vital for health. In order to cure or postpone age-related functional deterioration and disease, it is necessary to identify which precursor cells regulate the rates of aging in various biological systems. Dr. Harrison and his associates are testing the degree to which senescence of the female...
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Dr. Kevin D. Mills
Jackson Laboratory
2006 new Scholar Award in aging
The DNA damage theory of aging states that accumulation of DNA damage or chromosomal abnormalities over time can lead to decreasing cell function, and that the additive effects of such damage result in aging. This theory has been partially tested using mouse as an experimental system, where mouse strains with engineered deficiencies in DNA repair...
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Dr. Chengkai Dai
Jackson Laboratory
2009 new Scholar Award in aging
In humans, aging is associated with two major life-threatening diseases: neurodegeneration and cancer. A number of theories have been proposed to account for the aging process. The stress theory of aging emphasizes that stressful environments cause cellular damages, disruption of cellular functions, and eventual organismal aging. In strong support...
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Dr. Andrew Brack
Jackson Laboratory
2009 new Scholar Award in aging
Organismal aging is characterized by a decline in regenerative capacity leading to reduced physiological function. Skeletal muscle has an impaired regenerative response during aging, largely due to defects in the muscle stem cells (the satellite cells), which are almost solely responsible for muscle regeneration. Throughout life, skeletal... |
Non-Scholar Awards for Jackson Laboratory
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2005 Infrastructure Scholar Award in Aging
The Ellison Medical Foundation has pledged up to $1,548,094 for a 4 year period to support the systematic analysis of histopathology in aging mice at 1 year, 2 years, and near death. The studies will provide information on common features of aging across multiple strains, genetic variation of age-related changes, and models on age-related...
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2005 Infrastructure Scholar Award in Aging
The Ellison Medical Foundation has pledged up to $2,200,000 over 2 years to The Jackson Laboratory to characterize mice for age-related phenotypes and make this data available to researchers in the Mouse Phenome Database. The age-related phenotypes will include hormones of aging, immunological changes with age, neuromuscular function, changes in...
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2004 Infrastructure Scholar Award in Aging
The Ellison Medical Foundation has awarded up to $1,014,000, over a period of four years, to expand genetic tools for the mouse model systems used in aging research. The award will support the characterization of lifespan and aging-related phenotypes of genetically diverse and commonly used inbred mouse strains. The data will be publicly...
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2003 Infrastructure Scholar Award in Other
The Ellison Medical Foundation has awarded $750,000 to fund the construction of the Genetic Repository Center at The Jackson Laboratory in Bar Harbor, Maine. This Repository will consolidate small mouse colonies, of strains that are in steady demand, into a single breeding facility. The resources will include models for Type 1 diabetes,...
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2003 Infrastructure Scholar Award in Other
The Jackson Laboratory received a second award in the amount of $945,000 to fund research and education on cryopreservation techniques. Scientists from around the world will receive training through courses on cryopreservation with the goal of moving the biomedical research community to order cryopreserved embryos or reproductive cells of mice,...
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1998 Infrastructure Scholar Award in Aging
Genetically defined mice have become the models of choice for an array of diseases associated with aging. The Jackson Laboratory has long been a national resource for the development, analysis, and distribution of laboratory mice that serve as models for studying human biology and disease. The Jackson Laboratory's genetic resources incorporate the...
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2000 Conferences and Workshops Scholar Award in Aging
The Jackson Laboratory, Bar Harbor, ME, was awarded $10,000 to help fund its 3rd Genetics of Aging Meeting held August 4-8, 2000. The focus of the meeting was on a comparative genomic approach for identifying genes that increase life spans in multiple biological organisms and suggest basic mechanisms of aging, and identifying research directions...
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Funded Institutions
The Ellison Medical Foundation fosters research by means of grants-in-aid on behalf of investigators to universities and laboratories within the United States. Institutions receiving awards must be tax-exempt 501(c)(3) organizations or U.S. colleges or universities.
The Ellison Medical Foundation