Myelodysplastic syndrome (MDS) and myeloproliferative disorders (MPD) are clonal hematopoietic (blood-forming) disorders primarily affecting patients over the age of 65. These disorders arise in hemtopoietic stem cells (HSC), are associated with an increased risk of progression to acute myeloid... >> MORE

Immunosenescence is believed to be an important component of old age and may be related to tumorigenesis and to susceptibility to virus infections. Very little is known about its mechanism, particularly in molecular terms. In the past five years natural killer cell (NK) and dendritic cell (DC)... >> MORE

The immune system is central to human health and its impairment or dysfunction can have severe or even fatal consequences. One of the hallmarks of aging is the progressive loss of immune function, exposing older people to increased risk from infectious diseases that would not normally be more than... >> MORE

The research in my laboratory concerns aspects of quality control in protein synthesis. The failure rate in protein synthesis is substantial, which necessitates a reliable means of disposal for these error-containing and therefore unwanted proteins. The risk associated with accumulation of... >> MORE

The human immune system deteriorates with age in a process termed Immunosenescence, significantly impacting health and overall survival. The risk of death from infection increases dramatically by age 65, the efficacy of vaccination drops, and the increased rate of cancer seen in the elderly has... >> MORE

The age-associated decline in immune function with advancing age, termed immunosenescence, has been well documented in humans, but the underlying mechanisms remain poorly understood. Indeed, the decline in immune function itself may contribute to the aging process. We propose to identify and... >> MORE

Increased susceptibility to infectious diseases is one of the main problems associated with old age. Underlying this susceptibility are diverse age-related changes in the immune system, including reduced repertoire of white blood cells, impaired antibody responses and enhanced proinflammatory...

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Decline in immune function is a hallmark of aging, leading to increased susceptibility to infections and reduced response to vaccination in the elderly population. Paradoxically this decline in immune function is associated with low grade chronic inflammation and increased incidence of diseases... >> MORE

The over-65s account for a major portion of all health care costs. Aging renders this group especially susceptible to infections and current concerns about avian influenza virus and the increased severity of SARS and West Nile Virus in the elderly have highlighted this issue. Declining immune... >> MORE

In Alzheimer's disease, a chronic inflammatory response to β-amyloid has been proposed to underly neuro-degenerative pathology. Central to this hypothesis is the observation that microglia are recruited to, and accumulate at, sites of β-amyloid deposition. These cells produce...

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To understand the complex processes underlying human aging, the study of cellular "senescence" may recapitulate some aspects. Senescence is a cell fate program that can be triggered by environmental stimuli and stress. We have recently discovered that the major stress-inducible transcription...

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The majority of patients with cancer in the United States are more than 70 years old and cancer has been regarded as a disease of aging. Aging-related decline of the immune response has also been well documented. Our long-term goals are to identify molecular targets for drug development...

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Stem cells are present in many adult tissues, where they serve to replenish the cells of that tissue as they become exhausted. The role of stem cells in aging is not completely understood - one might expect that if stem cells were able to perform ideally, they would be able to refresh the cells of... >> MORE

We study the way that aging and immunity interact with each other. The only way we have now of extending the lifespan of a healthy person is through diet restriction. We found it interesting that when animals get infected they often become anorexic and this reduces food intake in the same way as... >> MORE

Immunosenescence is the deterioration of immune function that accompanies aging and that contributes to age-dependent increases in infection, mortality, and potentially cancer. Dietary restriction is a manipulation whereby exposing experimental animals to a reduced-calorie environment extends...

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